Research and Development

Most recent publications

Ramalho B, Penedones A, Mendes D, Alves C. Quality of Systematic Reviews with Network Meta-Analyses on JAK Inhibitors in the Treatment of Rheumatoid Arthritis: Application of the AMSTAR 2 Scale. J. Clin. Med. 2026, 15 (2):725. doi: 0.3390/jcm15020725. https://www.mdpi.com/2077-0383/15/2/725

Mendes D, Figueiredo D, Alves C, Amaral R, Costa B, Penedones A, Batel-Marques F. The impact of the COVID-19 pandemic on arterial hypertension monitoring in Portugal. Revista Portuguesa de Cardiologia. 2025 Sep. doi: 10.1016/j.repc.2025.06.005 https://www.revportcardiol.org/pt-the-impact-covid-19-pandemic-on-avance-S0870255125002616

Alves C, Penedones A, Mendes D, Batel Marques F. ACE inhibitors and ARBs and the risk of acute pancreatitis: a meta-analysis of observational studies.  Cureus. 2025 Sep;17(9): e93136. doi:10.7759/cureus.93136. Epub 2025 Sep 24. PMID: 41000144 https://www.cureus.com/articles/412335-angiotensin-converting-enzyme-inhibitors-angiotensin-ii-receptor-blockers-and-the-risk-of-acute-pancreatitis-a-systematic-review-and-meta-analysis#!/

Penedones A, Mendes D, Alves C, Filipe A, Oliveira T, Batel-Marques F. Relationship Between Chronic Obstructive Pulmonary Disease and Osteoporosis: A Scoping Review. Copd. 2024;21(1):2356510. https://doi.org/10.1080/15412555.2024.2356510

Mendes D, Figueiredo D, Alves C, Penedones A, Costa B, Batel-Marques F. Impact of the COVID-19 pandemic on cancer screenings in Portugal. Cancer Epidemiol. 2024;88:102496. https://doi.org/10.1016/j.canep.2023.102496

Alves C, Mendes D, Penedones A, Oliveira T, Donato A, Batel-Marques F. The effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies. Int J Clin Pharm. 2024;46(2):357-67. https://doi.org/10.1007/s11096-023-01666-x

Mendes D, Penedones A, Alves C, Oliveira T, Donato A, Batel-Marques F. Ibandronate in the Prevention of Vertebral and Nonvertebral Osteoporotic Fractures: A Systematic Review of Experimental and Observational Studies. J Clin Rheumatol. 2023;29(2):78-83. https://doi.org/10.1097/RHU.0000000000001902

Alves C, Penedones A, Mendes D, Batel Marques F. Topical Janus kinase inhibitors in atopic dermatitis: a safety network meta-analysis. Int J Clin Pharm. 2023;45(4):830-8. https://doi.org/10.1007/s11096-023-01569-x

Most recent communications

Ribeiro C, Teles C, Costa B, Amaral R, Mendes D, Alves C. CO64 Correlation between extension survival benefits and incremental costs of oncology drugs in Portugal: a cross-sectional, regression analysis. Value in Health. Volume 28, Issue 12, Supplement 1S54. DOI: https://doi.org/10.1016/j.jval.2025.09.166

Ramalho B, Penedones A, Mendes D, Alves C.SA78 Quality of Systematic Reviews with Network Meta-Analyses on JAK Inhibitors in the Treatment of Rheumatoid Arthritis: Application of the AMSTAR 2 Scale. Value in Health Volume 28, Issue 12, Supplement 1, S661. DOI: https://doi.org/10.1016/j.jval.2025.09.3019

Alves C, Costa B, Amaral R, Penedones A, Mendes D, Batel Marques F. CO95 Efficacy and safety of once-weekly and once-daily basal insulins in type 1 diabetes mellitus: a systematic review and network meta-analysis of clinical trials. Value in Health, Volume 28, Issue 12, Supplement 1, S60. DOI: https://doi.org/10.1016/j.jval.2025.09.197

Teodoro P, Mendes D, Alves C.  CO49 Clinical outcomes in hta appraisal reports of oncologymedicines in portugal: A cross-sectional analysis. Value in Health, Volume 28, Issue 12, Supplement 1S50-S51, DOI: https://doi.org/10.1016/j.jval.2025.09.151.

Costa B, Amaral R, Penedones A, Ramírez Alcántara D, Mendes D, Alves C. CO92 Efficacy and safety of inhaled levofloxacin versus other inhaled antibiotics in the treatment of adults with cystic fibrosis and chronic Pseudomonas aeruginosa lung infection: an updated network meta-analysis. Value in Health, Volume 28, Issue 12, Supplement 1, S60. DOI: https://doi.org/10.1016/j.jval.2025.09.194.

Mendes D, Alves C, Figueiredo D, Costa B, Penedones A, Ramirez de Arellano A. EE70 Avacopan in the treatment of ANCA-associated vasculitis: a cost-utility analysis in Portugal. Value in Health, Volume 28, Issue 12, Supplement 1, S113. DOI: https://doi.org/10.1016/j.jval.2025.09.454.

Mendes D, Figueiredo D, Alves C, et al. EPH80 Impact of the COVID-19 Pandemic on Arterial Hypertension Monitoring and Control in Portugal. Value in Health. 2024;27(12):S236-S237. https://doi.org/10.1016/j.jval.2024.10.1210

Costa B, Alves C, Mendes D, et al. CO51 Second-Line Pharmacological Interventions for Advanced Non-Small Cell Lung Cancer in MetEX14 Skipping Patients: A Systematic Literature Review. Value in Health. 2024;27(12):S24. https://doi.org/10.1016/j.jval.2024.10.128

Sousa A, Alves C, Batel Marques F, Mendes D. HTA178 The Health Technology Assessment System in Portugal: A Study on Medicines Reimbursement Recommendations. Value in Health. 2024;27(12):S389. https://doi.org/10.1016/j.jval.2024.10.2003

Nobrega E, Alves C, Batel Marques F, Mendes D. HTA177 Reasons for Drug Market Access Failure in Portugal: A Retrospective Analysis of Public Reimbursement Reports. Value in Health. 2024;27(12):S388. https://doi.org/10.1016/j.jval.2024.10.2002

Matos P, Mendes D, Batel Marques F, Alves C. HTA170 Use of Off-Label Comparators in Health Technonology Assessment in Portugal: A Review of Reimbursement Appraisal Reports. Value in Health. 2024;27(12):S387. https://doi.org/10.1016/j.jval.2024.10.1995

Mendes D, Figueiredo D, Alves C, et al. EPH79 Impact of the COVID-19 Pandemic on Diabetes Mellitus Care in Portugal. Value in Health. 2024;27(12):S236. https://doi.org/10.1016/j.jval.2024.10.1209

Alves C, Penedones A, Mendes D, Batel Marques F. EPH8 Risk of Acute Pancreatitis Associated With ARBs and ACE Inhibitors: A Meta-Analysis of Observational Studies. Value in Health. 2024;27(12):S224. https://doi.org/10.1016/j.jval.2024.10.1140

Mendes D, Figueiredo D, Alves C, et al. P10 Impact of the COVID-19 Pandemic on Cancer Screenings in Portugal and Years of Life Lost Due to Delayed Diagnoses. Value in Health. 2023;26(12):S2-S3. https://doi.org/10.1016/j.jval.2023.09.012

Ribeiro C, Penedones A, Mendes D, Alves C. HTA338 Characterization of the Evidence Supporting the Relative Effectiveness Evaluations in Health Technologies Assessment: A Review. Value in Health. 2023;26(12):S385. https://doi.org/10.1016/j.jval.2023.09.2021

Ribeiro C, Penedones A, Mendes D, Alves C. HTA46 Relationship Between the Directness of the Evidence and Identification of Added Therapeutic Value: An Analysis of HTA Procedures. Value in Health. 2023;26(12):S328-S329. https://doi.org/10.1016/j.jval.2023.09.1731