Evidence Review, Synthesis and Generation

Protocol and planification for evidence generation strategy

A systematic literature review identifies, appraises and synthesises all the relevant studies on a defined question, following a protocol set in advance. When the data allow, meta-analysis, network meta-analysis and indirect treatment comparisons combine the results to compare treatments for HTA and reimbursement decisions.

Protocol planification in evidence review and synthesis ensures methodological transparency and reduces bias by establishing predefined criteria for evidence selection and analysis. It allows for comprehensive evidence synthesis, offering more robust conclusions through a clearer understanding of the clinical value of interventions.

Our offering includes

Systematic review, narrative review, scoping review, and umbrella review
Evidence gap analysis
Assessment of the efficacy, effectiveness, and safety of therapeutic interventions
Health-related quality of life (HRQoL)
Disease epidemiology
Burden of disease
Assessing the feasibility of performing meta-analysis
Conventional meta-analysis
Network meta-analysis and indirect treatment comparisons
Value communication, including scientific journals and conferences publications and presentations

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FAQ

Frequently Asked Questions

Why is important to draw a protocol and plan evidence review, synthesis and generation?

Drawing a protocol for evidence review, synthesis, and generation is crucial as it minimizes bias, ensures consistency and reproducibility, enhances efficiency and focus, and helps identify gaps in knowledge to guide future research.

How does Clevidence provide good work on evidence review, synthesis and generation?

Clevidence has expert teams with specialized knowledge in systematic reviews and meta-analyses, ensuring rigorous and transparent methodologies. We conduct comprehensive literature searches across multiple databases to gather all relevant studies. Use of statistical software performs robust data analyses and generate reliable insights. Additionally, Clevidence complies guidelines and regulatory standards to meet the specific client needs, with the aim of provide technically rigourous reports.

Proven Success with Evidence Review and Synthesis

Informing Healthcare Decision-Making

Clevidence’s team has conducted several systematic reviews and meta-analyses, including network meta-analyses and indirect treatment comparisons, in accordance with the highest methodological standards to synthesize evidence for comparative effectiveness analyses of health technologies. These reviews have generated evidence that is valuable for guiding clinical decision-making and supporting health technology assessment (HTA) processes.

The services supported policy decisions that enhanced treatment accessibility and resource efficiency.