Budget Impact Analysis of a Treatment for Peripheral Neuropathic Pain in Portuguese Hospitals
Clevidence developed budget impact models and locally adapted HEOR evidence to support the hospital market access strategy of a treatment for peripheral neuropathic pain in Portugal. The analysis integrated treatment costs, concomitant medication use, and healthcare resource utilisation across three distinct clinical populations, enabling the client to quantify the financial impact of treatment adoption within Portuguese NHS hospitals.
Integrated Support for the HTA and Reimbursement Process in Portugal
Challenge A pharmaceutical company required support throughout the Health Technology Assessment (HTA) and reimbursement process in Portugal for a medicine intended to treat a pulmonary infection. The process required the preparation and adaptation of a body of clinical and economic evidence, aligned with the anticipated requirements of the national HTA authority. In particular, it was […]
Localising a Cost Calculator to Support Market Access in Portugal
Challenge A pharmaceutical company required a localized cost calculator to support the market access strategy for a new therapy in Portugal. The objective was to demonstrate the economic impact of the new treatment compared with the current standard of care, providing robust, country-specific evidence to support value communication with key healthcare stakeholders. The original calculator […]
Translating Respiratory Disease Evidence into Medical Education
Challenge A pharmaceutical company aimed to develop medical education materials for Portuguese physicians to enhance awareness of the comorbidities associated with a progressive respiratory disease and promote a more structured and holistic approach to patient management. While a substantial body of scientific evidence existed, the information was scattered across numerous publications, making it difficult to […]
Validation of health economic model assumptions through expert elicitation
Challenge A pharmaceutical company was preparing the reimbursement submission for a new treatment for a renal disease and needed to adapt a cost-effectiveness model (CEM) and a budget impact model (BIM) to the Portuguese setting. However, there was uncertainty regarding clinical practice in Portugal, particularly concerning treatment patterns, patient monitoring, healthcare resource utilization, and the […]
Advanced indirect comparisons to support HTA decision-making
Challenge A therapy developed for a rare and severe genetic disease required robust comparative evidence to support evaluation within an HTA process and inform reimbursement decision-making. However, the available evidence was derived from trials with heterogeneous patient populations and varying treatment durations, thereby limiting the validity of conventional cross-trial comparisons. Solution A stepwise analytical approach […]
Statin Safety Evidence, Clarified: An Umbrella Review for Scientific Communication
Challenge The safety of statins has been extensively studied, resulting in a large and heterogeneous body of systematic reviews and meta-analyses. Translating this complex evidence base into clear, credible insights for medical affairs communication requires a structured and methodologically robust synthesis. Solution Clevidence designed and conducted an umbrella review, consolidating evidence from systematic reviews and […]
Bridging the Evidence Gap in HTA: Indirect Comparisons to Support Reimbursement Decision-Making
Challenge A pharmaceutical company sought to demonstrate the efficacy and safety of a novel therapy for adults with persistent urinary symptoms who had previously received first-line pharmacological treatment. A key challenge in the HTA evaluation was the absence of head-to-head clinical trials comparing the therapy with the primary comparator considered relevant by the HTA authority. […]
Evaluating the Impact of the COVID-19 Pandemic on NHS Cancer Screening and Outcomes
Client: A Healthcare Organization Challenge:A healthcare organization sought to assess the COVID-19 pandemic’s impact on NHS cancer screening performance. They aimed to determine how disruptions affected cancer morbidity and mortality rates, posing significant challenges for public health management. Solution Provided by Clevidence:Clevidence was engaged to conduct a comprehensive study involving several key steps: Results:The study […]
Enhancing Awareness of the Relationship Between Two Clinical Conditions
Client: A Pharmaceutical Company Challenge:A pharmaceutical company sought to create communication materials for medical sales visits and scientific exchange meetings to raise awareness of the relationship between two clinical conditions. The objective was to highlight data on epidemiology, risk factors, and the importance of monitoring patients with one condition for potential development of the other. […]